Because of this, tissue concentrations are significantly greater than are plasma concentrations. Azithromycin is distributed widely into brain tissue however, not into cerebrospinal fluid or the aqueous humor of the attention. Protein binding varies with plasma concentration; 51% of the drug is bound at low concentrations (0.02 mcg/ml) and this binding decreases to 7% at higher concentrations (2 mcg/ml). Azithromycin has a long half-life in both adults and children , which is partially explained by its considerable tissue uptake and slow release. Elimination is basically in the feces, following excretion in to the bile, with less than 14% excreted in the urine. 250 to 500 mg PO 3 days per week has been recommended to reduce exacerbation rates.
Prescribing ZITHROMAX in the lack of a successful or strongly suspected infection is unlikely to provide benefit to the individual and escalates the risk of the development of drug-resistant bacteria. Local IV site reactions have been reported with the intravenous administration of azithromycin. The incidence and severity of these reactions were the same when 500 mg azithromycin was given over one hour (2 mg/mL as 250 mL infusion) or higher 3 hr (1 mg/mL as 500 mL infusion) . All volunteers who received infusate concentrations above 2.0 mg/mL experienced local IV site reactions and, therefore, higher concentrations should be avoided.
In controlled clinical studies, azithromycin has been administered to pediatric patients age 6 months to 16 years by the oral route. Pharmacokinetics of azithromycin following oral administration in older volunteers yrs . old were just like those in younger volunteers years of age for the 5-day therapeutic regimen. No overall variations in safety were observed between these subjects and younger subjects in conditions of adverse events, laboratory abnormalities, and discontinuations. Almost all antibacterial agents, including systemic azithromycin, have been associated with pseudomembranous colitis or C.
ZITHROMAX and other medicines may affect one another leading to side effects. ZITHROMAX may affect the way other medicines work, and other medicines may affect how ZITHROMAX works. Contact your doctor immediately if you are giving ZITHROMAX to a kid and she or he vomits or becomes irritable when fed. have a history of cholestatic jaundice or hepatic dysfunction that happened by using azithromycin. Pharmacokinetic parameters in older volunteers were a lot like those in adults for the 5-day therapeutic regimen.
Don’t stop taking this medicine, even if your symptoms subside. You should learn to feel better within a few days of taking azithromycin, but this will be based upon the kind of infection you have. Follow all directions on your prescription label and read all medication guides or instruction sheets. The merchandise information provided by this site is intended only for health care professionals, patients, consumers and caregivers in america. The products discussed herein may have different product labeling in several countries.
Advise women to monitor breast-fed infant for diarrhea, vomiting, or rash. Assess patient for skin rash frequently during therapy. Discontinue azithromycin initially sign of rash; may be life-threatening. Stevens-Johnson syndrome or toxic epidermal necrolysis may develop.